Cutaneous Adverse Reactions of Amiodarone
نویسندگان
چکیده
Dermatological complications of amiodarone are commonly encountered problems in therapy. The incidence in the population of patients with prolonged use of amiodarone reaches nearly 75% according to various sources. Nevertheless, they are often misdiagnosed or overlooked. The aim of this review is to present the current state of knowledge about skin changes induced by amiodarone, including phototoxic and photoallergic reactions, as well as hyperpigmentation. In most cases, the adverse effects are reversible and disappear after discontinuation of the drug. Although the dermatological complications usually do not influence the outcome of the therapy and rarely cause discontinuation of treatment, they have a great impact on patient quality of life.
منابع مشابه
Cutaneous adverse drug reactions: A one year prospective study
Background: Adverse cutaneous drug reactions are unwarranted effects of modern medicine. These unfortunate events can assume any morphology from simple exanthem to full blown toxic epidermal necrolysis (TEN), and can simulate and mimic many diseases. Sometimes it is difficult to recognize the cause, but they may be due to polypharmacy or self-administration of medications. The analytical data f...
متن کاملعلل و انواع بالینی واکنشهای دارویی ناخواستهی پوستی در بیماران مراجعهکننده به بیمارستان فرشچیان همدان در سالهای 87 و 88
Background and Aim: Adverse drug reactions are inevitable outcomes of drug therapy, which may cause mortality and morbidity for those whom are treated in this way. Cutanous adverse drug reactions are abserved in 2% to 3% of inpatients but only 2% of them are considered serious and may cause death. The aim of this study was to determine the cause and clinical forms of adverse drug reactions refe...
متن کاملClinical and Laboratory Features of Anticonvulsant Cutaneous Reactions
Background: Cutaneous drug reaction is a common side effect of antiepileptic drugs (AEDs). In recent years, a significant increase in cases of cutaneous drug reaction due to AEDs and some changes in its pattern in our department have been noticed. Therefore, we carried out this study to present clinical and paraclinical characteristics of these cases. Methods: All records of patients who were h...
متن کاملAnticonvulsant Drugs and Severe Adverse Cutaneous Drug Reactions: A Longitudinal Observational Study
Background: Severe Adverse Cutaneous Reactions to Drugs (SACRDs) are skin eruptions due to drugs, which can cause morbidity and morbidity in patients. Objectives: The aim of this study was to determine the offending drug/agents and clinical phenotypes of SACRDs leading to admissions to the hospital. Materials & Methods: We conducted a retrospective cross-sectional study during one year (March...
متن کاملAmiodarone-induced vasculitis and polyserositis.
A dose-dependent cutaneous leukocytoclastic vasculitis developed in a 34 year old man who was given amiodarone for supraventricular tachycardias resistant to other drugs. This adverse reaction disappeared within 2 weeks after discontinuation of amiodarone despite its very long half-life of 52 days in this patient. During previous treatment periods with amiodarone, the patient had experienced ph...
متن کامل